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SkillHub ClubWrite Technical DocsData / AITech Writer

variant-annotation

Query and annotate gene variants from ClinVar and dbSNP databases. Trigger when: - User provides a variant identifier (rsID, HGVS notation, genomic coordinates) and asks about clinical significance - User mentions "ClinVar", "dbSNP", "variant annotation", "pathogenicity", "clinical significance" - User wants to know if a mutation is pathogenic, benign, or of uncertain significance - User provides VCF content or variant data requiring interpretation - Input: variant ID (rs12345), HGVS notation (NM_007294.3:c.5096G>A), or genomic coordinates (chr17:43094692:G>A) - Output: clinical significance, ACMG classification, allele frequency, disease associations

Packaged view

This page reorganizes the original catalog entry around fit, installability, and workflow context first. The original raw source lives below.

Stars
3,125
Hot score
99
Updated
March 20, 2026
Overall rating
C4.0
Composite score
4.0
Best-practice grade
C62.3

Install command

npx @skill-hub/cli install openclaw-skills-variant-annotation

Repository

openclaw/skills

Skill path: skills/aipoch-ai/variant-annotation

Query and annotate gene variants from ClinVar and dbSNP databases. Trigger when: - User provides a variant identifier (rsID, HGVS notation, genomic coordinates) and asks about clinical significance - User mentions "ClinVar", "dbSNP", "variant annotation", "pathogenicity", "clinical significance" - User wants to know if a mutation is pathogenic, benign, or of uncertain significance - User provides VCF content or variant data requiring interpretation - Input: variant ID (rs12345), HGVS notation (NM_007294.3:c.5096G>A), or genomic coordinates (chr17:43094692:G>A) - Output: clinical significance, ACMG classification, allele frequency, disease associations

Open repository

Best for

Primary workflow: Write Technical Docs.

Technical facets: Data / AI, Tech Writer.

Target audience: Bioinfo teams looking for install-ready agent workflows..

License: Unknown.

Original source

Catalog source: SkillHub Club.

Repository owner: openclaw.

This is still a mirrored public skill entry. Review the repository before installing into production workflows.

What it helps with

  • Install variant-annotation into Claude Code, Codex CLI, Gemini CLI, or OpenCode workflows
  • Review https://github.com/openclaw/skills before adding variant-annotation to shared team environments
  • Use variant-annotation for bioinfo workflows

Works across

Claude CodeCodex CLIGemini CLIOpenCode

Favorites: 0.

Sub-skills: 0.

Aggregator: No.

variant-annotation | SkillHub